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Solid-phase synthesis of N-(pyrimidin-2-yl)amino acid amides
| Content Provider | CiteSeerX |
|---|---|
| Author | Ermolat’ev, Denis S. Babaev, Eugene V. |
| Abstract | A series of new primary amides of N-(pyrimidin-2-yl)amino acids were prepared using solid-phase chemistry techniques. Various protected amino acids were immobilized onto Rink resins and deprotected. Reaction with 2-fluoropyrimidines followed by cleavage from the resin afforded the target compounds in good yields. A general method for the synthesis of amino acid derivatives N-aminosubstituted with a heterocyclic core has been found, and the advantage of the solid-phase approach is also discussed. |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Solid-phase Synthesis Amino Acid Amide Amino Acid Solid-phase Approach Solid-phase Chemistry Technique General Method Amino Acid Derivative Rink Resin Heterocyclic Core New Primary Amide Good Yield |
| Content Type | Text |
