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“Stealth ” tumors Breast cancer cells shun NK-cells anti-tumor immunity
| Content Provider | CiteSeerX |
|---|---|
| Author | Mamessier, Emilie Bertucci, François Sabatier, Renaud Birnbaum, Daniel Olive, Daniel |
| Abstract | Breast cancers (BCs) comprise heterogeneous subtypes of various prognoses. An active anti-tumor immune profile usually correlated with a better survival. Two current major challenges of BC research are to understand the inter-relations between BC and anti-tumor immunity, and to identify candidates whose targeting would contribute to enhance anti-tumor efficiency. Innate immunity maintains poised police-men such as natural killer (NK) cells that recognize and destroy cells that turn into troublemakers, as is the case of tumor cells. NK-cells, but also other members of anti-tumor immunity, have this natural ability to distinguish normal cells from “modi-fied ” cancer cells through the expression of inhibitory and activating receptors trig-gered during target-cell recognition. The majority of inhibitory receptors are specific |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Anti-tumor Immunity Current Major Challenge Normal Cell Active Anti-tumor Immune Natural Killer Inhibitory Receptor Bc Research Breast Cancer Natural Ability Heterogeneous Subtypes Target-cell Recognition Tumor Cell Various Prognosis Innate Immunity Maintains Modi-fied Cancer Cell Anti-tumor Efficiency Destroy Cell |
| Content Type | Text |
