Loading...
Please wait, while we are loading the content...
Similar Documents
Design of fault-tolerant and dynamically-reconfigurable microfluidic biochips (2005)
| Content Provider | CiteSeerX |
|---|---|
| Author | Su, Fei Chakrabarty, Krishnendu |
| Description | in Proc. Design, Automation and Test in Europe (DATE) Conference Microfluidics-based biochips are soon expected to revolutionize clinical diagnosis, DNA sequencing, and other laboratory procedures involving molecular biology. Most microfluidic biochips are based on the principle of continuous fluid flow and they rely on permanently-etched microchannels, micropumps, and microvalves. We focus here on the automated design of “digital ” droplet-based microfluidic biochips. In contrast to continuous-flow systems, digital microfluidics offers dynamic reconfigurability; groups of cells in a microfluidics array can be reconfigured to change their functionality during the concurrent execution of a set of bioassays. We present a simulated annealing-based technique for module placement in such biochips. The placement procedure not only addresses chip area, but it also considers fault tolerance, which allows a microfluidic module to be relocated elsewhere in the system when a single cell is detected to be faulty. Simulation results are presented for a case study involving the polymerase chain reaction. 1. |
| File Format | |
| Language | English |
| Publisher Date | 2005-01-01 |
| Access Restriction | Open |
| Subject Keyword | Continuous-flow System Module Placement Molecular Biology Dynamically-reconfigurable Microfluidic Biochip Placement Procedure Digital Droplet-based Microfluidic Biochip Concurrent Execution Automated Design Polymerase Chain Reaction Single Cell Case Study Simulated Annealing-based Technique Microfluidics-based Biochip Microfluidic Module Microfluidics Array Laboratory Procedure Microfluidic Biochip Chip Area Dna Sequencing Simulation Result Digital Microfluidics Offer Dynamic Reconfigurability Clinical Diagnosis Fault Tolerance Permanently-etched Microchannels Continuous Fluid Flow |
| Content Type | Text |
| Resource Type | Article |
