NDLI: A JOURNAL OF NEUROLOGY Neural systems for speech and song in autism

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A JOURNAL OF NEUROLOGY Neural systems for speech and song in autism

Content Provider	CiteSeerX
Author	Lai, Grace Schneider, Harry Hirsch, Joy Pantazatos, Spiro P.
Abstract	Despite language disabilities in autism, music abilities are frequently preserved. Paradoxically, brain regions associated with these functions typically overlap, enabling investigation of neural organization supporting speech and song in autism. Neural systems sensitive to speech and song were compared in low-functioning autistic and age-matched control children using passive auditory stimulation during functional magnetic resonance and diffusion tensor imaging. Activation in left inferior frontal gyrus was reduced in autistic children relative to controls during speech stimulation, but was greater than controls during song stimulation. Functional connectivity for song relative to speech was also increased between left inferior frontal gyrus and superior temporal gyrus in autism, and large-scale connectivity showed increased frontal–posterior connections. Although frac-tional anisotropy of the left arcuate fasciculus was decreased in autistic children relative to controls, structural terminations of the arcuate fasciculus in inferior frontal gyrus were indistinguishable between autistic and control groups. Fractional anisotropy correlated with activity in left inferior frontal gyrus for both speech and song conditions. Together, these findings indicate that in autism, functional systems that process speech and song were more effectively engaged for song than for speech and
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Subject Keyword	Neural Organization Passive Auditory Stimulation Increased Frontal Posterior Connection Speech Stimulation Left Inferior Frontal Gyrus Inferior Frontal Gyrus Left Arcuate Fasciculus Song Condition Journal Neurology Neural System Fractional Anisotropy Language Disability Frac-tional Anisotropy Superior Temporal Gyrus Structural Termination Music Ability Age-matched Control Child Arcuate Fasciculus Song Stimulation Large-scale Connectivity Autistic Child Functional System
Content Type	Text

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