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Hydrogel-Based Glucose Sensors: Effects of Phenylboronic Acid Chemical Structure on Response
| Content Provider | CiteSeerX |
|---|---|
| Author | Zhang, Chunjie Losego, Mark D. Braun, Paul V. |
| Abstract | ABSTRACT: Phenylboronic acids (PBAs) are being considered for glucose sensing and controlled insulin release, because of their affinity for diol-containing molecules. The interaction of immobilized PBAs in a hydrogel matrix with glucose can lead to volumetric changes that have been used to monitor glucose concentration and release insulin. Although the interaction of PBAs with diol-containing molecules has been intensively studied, the response of PBA-modified hydrogels as a function of the specific PBA chemistry is not well understood. To understand the interaction of immobilized PBAs with glucose in hydrogel systems under physiological conditions, the glucose-dependent volumetric changes of a series of hydrogel sensors functionalized with different classes of PBAs were investigated. The volume change induced by PBA-glucose interactions is converted to the diffracted wavelength shift by a crystalline colloidal array embedded in the hydrogel matrix. The PBAs studied contain varying structural parameters such as the position of the boronic acid on the phenyl ring, different substituents on PBAs and different linkers to the hydrogel backbone. The volumetric change of the PBA modified hydrogels is found to be highly dependent on the |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Hydrogel-based Glucose Sensor Phenylboronic Acid Chemical Structure Immobilized Pbas Volumetric Change Hydrogel Matrix Diol-containing Molecule Pba-modified Hydrogel Hydrogel System Physiological Condition Boronic Acid Glucose Sensing Glucose Concentration Different Substituents Hydrogel Backbone Structural Parameter Insulin Release Phenylboronic Acid Crystalline Colloidal Array Pba-glucose Interaction Specific Pba Chemistry Glucose-dependent Volumetric Change Volume Change Different Class Release Insulin Phenyl Ring Diffracted Wavelength Shift Different Linkers Hydrogel Sensor |
| Content Type | Text |
| Resource Type | Article |
