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Development/Plasticity/Repair Adaptation of Binaural Processing in the Adult Brainstem Induced by Ambient Noise
| Content Provider | CiteSeerX |
|---|---|
| Author | Siveke, Ida Leibold, Christian Schiller, Evelyn Grothe, Benedikt |
| Abstract | Interaural differences in stimulus intensity and timing aremajor cues for sound localization. Inmammals, these cues are first processed in the lateral and medial superior olive by interaction of excitatory and inhibitory synaptic inputs from ipsi- and contralateral cochlear nucleus neurons. To preserve sound localization acuity following changes in the acoustic environment, the processing of these binaural cues needs neuronaladaptation.Recentstudieshaveshownthatbinaural sensitivityadapts tostimulationhistorywithinmilliseconds,but theactualextent of binaural adaptation is unknown. In the current study, we investigated long-term effects on binaural sensitivity using extracellular in vivo recordings from single neurons in the dorsal nucleus of the lateral lemniscus that inherit their binaural properties directly from the lateral and medial superior olives. In contrast to most previous studies, we used a noninvasive approach to influence this processing. Adult gerbils were exposed for 2 weeks tomoderate noise with no stable binaural cue.We foundmonaural response properties to be unaffected by thismeasure. However, neuronal sensitivity to binaural cueswas reversibly altered for a fewdays. Computationalmodels of sensitivity to interaural time and level differences suggest that upregulation of inhibition in the superior olivary complex can explain the electrophysiological data. |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Ambient Noise Development Plasticity Repair Adaptation Adult Brainstem Induced Binaural Processing Interaural Difference Stimulus Intensity Week Tomoderate Noise Neuronal Sensitivity Superior Olivary Complex Inhibitory Synaptic Input Medial Superior Olive Long-term Effect Binaural Adaptation Noninvasive Approach Contralateral Cochlear Nucleus Neuron Sound Localization Acoustic Environment Interaural Time Lateral Lemniscus Current Study Foundmonaural Response Property Stable Binaural Cue Vivo Recording Adult Gerbil Dorsal Nucleus Binaural Cue Sound Localization Acuity Single Neuron Timing Aremajor Cue Binaural Property Level Difference Recentstudieshaveshownthatbinaural Sensitivityadapts Tostimulationhistorywithinmilliseconds Binaural Sensitivity Electrophysiological Data |
| Content Type | Text |
