NDLI: Time Course of Humoral and Cell-Mediated Immune Responses to (2002)

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Time Course of Humoral and Cell-Mediated Immune Responses to (2002)

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Abstract	The time course of cell-mediated and humoral immune responses was elucidated in eight women with human papillomavirus type 16 (HPV-16) infection by performing serial HPV-16 E6 and E7 cytotoxic T-lymphocyte (CTL) assays and HPV-16 virus-like particle (VLP) antibody analyses. Four subjects had a single incident of HPV-16 DNA detection, and four subjects had two periods of HPV-16 DNA detection. In two of the women in the latter group, the second episode of HPV-16 detection occurred in the presence of high titers of HPV-16 VLP antibody, bringing into question the protective role of humoral immunity in preventing repeated infection. However, all four subjects rapidly became HPV-16 DNA negative following the second detection of HPV-16 DNA, suggesting the presence of immunological memory. In addition, one subject rapidly became negative for HPV-16 DNA despite having no evidence of CTL or VLP antibody response prior to the second HPV-16 DNA detection, suggesting the presence of immunological responses at an undetectable level. Overall, seven of eight subjects (88%) had detectable HPV-16 E6 and/or E7 CTL responses and seven of eight women (88%) had detectable HPV-16 VLP antibody responses. The association between human papillomavirus (HPV) and the development of cervical cancer is well known, with HPV type 16 (HPV-16) being the most common type found in these
File Format	PDF
Publisher Date	2002-01-01
Access Restriction	Open
Subject Keyword	Time Course Cell-mediated Immune Hpv-16 Dna Hpv-16 Dna Detection High Titer Single Incident Hpv-16 Vlp Antibody Detectable Hpv-16 Vlp Antibody Response Latter Group Human Papillomavirus Type Humoral Immunity Humoral Immune Response Hpv Type Second Detection Undetectable Level Human Papillomavirus Vlp Antibody Response Immunological Response Second Episode Protective Role Cervical Cancer Second Hpv-16 Dna Detection Hpv-16 Virus-like Particle Hpv-16 Detection Serial Hpv-16 E6 Immunological Memory Detectable Hpv-16 E6 E7 Ctl Response Common Type Repeated Infection
Content Type	Text

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