NDLI: Alcohol attenuates load-related activation during a working memory task: relation to level of response to alcohol (2006)

Please wait, while we are loading the content...

Alcohol attenuates load-related activation during a working memory task: relation to level of response to alcohol (2006)

Content Provider	CiteSeerX
Author	Paulus, Martin P. Tapert, Susan F. Pulido, Carmen Schuckit, Marc A.
Abstract	Background: A low level of response to alcohol is a major risk factor for the development of alcohol dependence, but neural correlates of this marker are unclear. Method: Ten healthy volunteers were classified by median split on level of response to alcohol and underwent 2 sessions of functional magnetic resonance imaging following ingestion of a moderate dose of alcohol and a placebo. The blood oxygen level–dependent activation to an event-related visual working memory test was examined. Results: The subjects exhibited longer response latencies and more errors as a function of increas-ing working memory load and showed a load-dependent increase in activation in dorsolateral prefrontal cortex, posterior parietal cortex, and visual cortex. Alcohol did not affect performance (errors or response latency), but attenuated the working memory load–dependent activation in the dorsolateral prefrontal cortex. During the placebo condition, individuals with a low level of response to alcohol showed greater activation in dorsolateral prefrontal cortex and posterior parietal cortex than those with a high level of response to alcohol. During the alcohol condition, groups showed similar attenuation of load-dependent brain activation in these regions. Conclusion: Low-level responders relative to high-level responders exhibited an increased work-
File Format	PDF
Publisher Date	2006-01-01
Access Restriction	Open
Subject Keyword	Working Memory Task Load-related Activation Dorsolateral Prefrontal Cortex Posterior Parietal Cortex Low Level Response Latency Memory Test Median Split Load-dependent Brain Activation Blood Oxygen Level Dependent Activation Low-level Responder Healthy Volunteer Visual Cortex Affect Performance Similar Attenuation Alcohol Dependence Moderate Dose Memory Load Memory Load Dependent Activation Major Risk Factor High-level Responder Neural Correlate Placebo Condition Functional Magnetic Resonance High Level Load-dependent Increase Alcohol Condition
Content Type	Text

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in