NDLI: EFFECTS OF MICROELECTRODE ARRAY CONFIGU- RATION AND POSITION ON THE THRESHOLD IN ELECTRICAL EXTRACELLULAR STIMULATION OF SINGLE NERVE FIBER: A MODELING STUDY

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EFFECTS OF MICROELECTRODE ARRAY CONFIGU- RATION AND POSITION ON THE THRESHOLD IN ELECTRICAL EXTRACELLULAR STIMULATION OF SINGLE NERVE FIBER: A MODELING STUDY

Content Provider	CiteSeerX
Author	Zhao, Xin-Tai Wang, Zhi-Gong
Abstract	Abstract—A transient finite-element model has been presented to simulate extracellular potential stimulating in a neural tissue by a nonplanar microelectrode array (MEA). This model allows simulating the extracellular potential and transmembrane voltage by means of a single transient computation performed within single finite element (FE) software. The differential effects of the configuration and position of MEA in electrical extracellular stimulation are analyzed theoretically. 3-D models of single nerve fiber and different MEA are used for the computation of the stimulation induced field potential, whereas a cable model of a nerve fibre is used for the calculation of the transmembrane voltage of the nerve fiber. The position of MEA and the spacing of the microelectrodes are varied while mono-, bi-, tri-, and penta-polar MEAs are applied. The model predicts that the lowest stimulation voltage threshold is obtained in the stimulation with penta-polar MEA. Moreover, the relationships, which exist between the thresholds of the electrical extracellular stimulation and the parameters including position of the electrode array and the spacing of the microelectrodes in array, are studied and obtained. 1.
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Subject Keyword	Modeling Study Electrical Extracellular Stimulation Transmembrane Voltage Stimulation Voltage Threshold Extracellular Potential Penta-polar Mea Transient Finite-element Model Extracellular Potential Stimulating Nerve Fiber Nerve Fibre Electrode Array Different Mea Single Finite Element Field Potential Single Nerve Fiber 3-d Model Nonplanar Microelectrode Array Penta-polar Meas Cable Model Neural Tissue Differential Effect Single Transient Computation
Content Type	Text

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