NDLI: Proto-organism kinetics: evolutionary dynamics of lipid aggregates with genes and metabolism, origins of life and evol. Of the biosphere (in press.

Content Provider	CiteSeerX
Author	Rasmussen, Steen Chen, Liaohai Stadler, Bärbel M. R. Stadler, Peter F.
Abstract	Abstract. A synthetic proto-organism could be self-assembled by integrating a lipid proto-container with a proto-metabolic subsystem and a proto-genetic subsystem. This three-component system can use energy and nutrients by means of either redox or photo-chemical reactions, evolve its proto-genome by means of template directed replication, and ultimately die. The evolutionary dynamics of the proto-organism depends crucially on the chemical kinetics of its sub-systems and on their interplay. In this work the template replication kinetics is investigated and it is found that the product inhibition inherent in the ligation-like replication process allows for coexistence of unrelated self-replicating proto-genes in the lipid surface layer. The combined catalytic effects from the proto-genes on the metabolic production rates determine the fate of the strain protocell.
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Subject Keyword	Evolutionary Dynamic Lipid Aggregate Proto-organism Kinetics Template Replication Kinetics Three-component System Product Inhibition Metabolic Production Rate Combined Catalytic Effect Lipid Proto-container Synthetic Proto-organism Strain Protocell Ligation-like Replication Process Proto-metabolic Subsystem Lipid Surface Layer Unrelated Self-replicating Proto-genes Photo-chemical Reaction Chemical Kinetics Proto-genetic Subsystem
Content Type	Text
Resource Type	Article

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