NDLI: Effects of chimerism on graft-versus-host disease, disease recurrence, and survival.

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Effects of chimerism on graft-versus-host disease, disease recurrence, and survival.

Content Provider	CiteSeerX
Author	Marrow, After Hla-Identical Md, Kamran Alimoghaddam Ghaffari, Hamid Md, Forough Foroughi Md, Zohreh Sanaat Md, Babak Bahar Md, Asadollah Mousavi Md, Masoud Iravani Md, Ardeshir Ghavamzadeh
Abstract	Background: The coexistence of recipient's and donor's hematopoietic systems after allogeneic marrow transplantation is called mixed chimerism. Objective: The objective of this study was to evaluate the effects of MC on graft-versus-host disease (GVHD), disease recurrence, and survival after HLA identical marrow transplantation in a transplant center in Iran. Methods: The association of MC with acute GVHD, disease recurrence, survival, and relapse-free survival was investigated in 91 patients who underwent either bone (n = 12) or peripheral blood (n = 79) HLA-identical marrow transplantation. Chimerism was assessed using multiplex amplification of short tandem repeats (STR). Patients had thalassemia (n = 19), acute myelogenous leukemia (AML) (n = 29), acute lymphocytic leukemia (ALL) (n = 20), chronic myelogenous leukemia (CML) (n = 18), and other diseases (n = 5). The median age was 21 (range: 3 – 50) years. There were 38 (42%) female and 53 (58%) male participants. Conditioning was made through busulfan plus cyclophosphamide in 34 patients; busulfan plus fludarabin in 51 patients; and busulfan plus fludarabin plus antithymocyte globulin in 6 patients. The median follow-up was 13 months.
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Subject Keyword	Disease Recurrence Effect Chimerism Graft-versus-host Disease Peripheral Blood Graft-versus-host Disease Transplant Center Antithymocyte Globulin Median Follow-up Relapse-free Survival Chronic Myelogenous Leukemia Median Age Male Participant Mixed Chimerism Acute Lymphocytic Leukemia Allogeneic Marrow Transplantation Myelogenous Leukemia Short Tandem Repeat Acute Gvhd Hematopoietic System Hla Identical Marrow Transplantation Multiplex Amplification Hla-identical Marrow Transplantation
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