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Effect of benztropine on haloperidol-induced prolactin.
| Content Provider | CiteSeerX |
|---|---|
| Author | Lal, S. Mendis, T. Cervantes, P. Guyda, H. Rivera, J. L. De Cholinergic, Prolactin Haloperidol, Benztropine |
| Abstract | Abstract. The effect of benztropine on haloperidol-induced prolactin secretion was investigated in 10 normal male volunteers. Benztropine had no. effect on basal prolactin secretion but significantly enhanced the increase induced by haloperidol. The magnitude of the enhancement, however,. was relatively small. These data suggest that in man cholinergic mechanisms have no effect on basal prolactin, secretion but exert a weak inhibitory effect under conditions of dopamine receptor block-ade. Differences in intrinsic anticholinergic properties may account for some of the variations in po-tency of different neuroleptics in increasing circulating prolactin concentrations. |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Haloperidol-induced Prolactin Dopamine Receptor Block-ade Weak Inhibitory Effect Basal Prolactin Secretion Different Neuroleptic Normal Male Volunteer Prolactin Concentration Man Cholinergic Mechanism Basal Prolactin Intrinsic Anticholinergic Property Haloperidol-induced Prolactin Secretion |
| Content Type | Text |
| Resource Type | Article |