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Quantification of Translocator Protein (18 kDa) in the Human Brain with PET and a Novel Radioligand, 18F-PBR06
| Content Provider | CiteSeerX |
|---|---|
| Author | Zoghbi, Sami S. Fujita, Masahiro Taku, Andrew Innis, Robert B. Pike, Victor W. Simè€on, Fabrice G. Fujimura, Yota |
| Abstract | Translocator protein (TSPO) (18 kDa), formerly called the periph-eral benzodiazepine receptor, is upregulated on activated microglia and macrophages and is, thus, a biomarker of inflam-mation. We previously reported that an 11C-labeled aryloxyani-lide (half-life, 20 min) was able to quantify TSPOs in the healthy human brain. Because many PET centers would benefit from a longer-lived 18F-labeled radioligand (half-life, 110 min), the ob-jective of this study was to evaluate the ability of a closely related aryloxyanilide (18F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline [18F-PBR06]) to quantify TSPOs in the healthy hu-man brain. Methods: A total of 9 human subjects were injected with 18F-PBR06 (;185 MBq) and scanned for 5 h, with rest pe-riods outside the camera. The concentrations of 18F-PBR06, separated from radiometabolites, were measured in arterial plasma. Results: Modeling of regional brain and plasma data |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Healthy Human Brain Arterial Plasma Novel Radioligand Periph-eral Benzodiazepine Receptor Many Pet Center Healthy Hu-man Brain Rest Pe-riods Related Aryloxyanilide Longer-lived 18f-labeled Radioligand Translocator Protein Plasma Data 2-phenoxyaniline 18f-pbr06 11c-labeled Aryloxyani-lide Activated Microglia Regional Brain |
| Content Type | Text |
