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Helicobacter pylori and peptic ulcer nomura et al. Relation between helicobacter pylori caga status and risk of peptic ulcer disease (2002).
| Content Provider | CiteSeerX |
|---|---|
| Author | Abraham M., Y. |
| Abstract | Although colonization with any Helicobacter pylori strain is associated with peptic ulcer, it is uncertain whether the risk is greater with cagA+ or cagA – strains, which differ in their biology. A nested case-control study was done, based on a cohort of 5,443 Japanese-American men examined on the Hawaiian island of Oahu from 1967 to 1970. A total of 150 men with gastric ulcer, 65 with duodenal ulcer, and 14 with both diseases were identified. The authors matched the 229 cases with 229 population controls and tested their serum for immunoglobulin G antibodies to H. pylori and immunoglobulin G antibodies to the cagA product of H. pylori using enzyme-linked immunosorbent assays. Persons with H. pylori positivity had an odds ratio of 4.0 (95 % confidence interval (CI): 1.9, 8.5) for gastric ulcer and 2.5 (95 % CI: 0.8, 7.4) for duodenal ulcer. For CagA positivity, the odds ratios were 1.4 (95 % CI: 0.9, 2.4) for gastric ulcer and 2.6 (95 % CI: 1.1, 5.8) for duodenal ulcer. Subjects who were seropositive for both H. pylori and CagA had an odds ratio of 4.4 (95 % CI: 1.8, 10.5) for gastric ulcer and 5.8 (95 % CI: 1.1, 30.0) for duodenal ulcer. The results suggest that colonization with a cag+ H. pylori strain elevates the risk beyond that of a cag – H. pylori strain for both gastric and duodenal ulcers. Am J Epidemiol 2002;155:1054–9. duodenal ulcer; Helicobacter pylori; peptic ulcer; stomach ulcer Received for publication July 2, 2001, and accepted for publica- |
| File Format | |
| Publisher Date | 2002-01-01 |
| Access Restriction | Open |
| Subject Keyword | Duodenal Ulcer Gastric Ulcer Caga Status Peptic Ulcer Nomura Odds Ratio Peptic Ulcer Disease Helicobacter Pylorus Peptic Ulcer Pylorus Strain Helicobacter Pylorus Strain Nested Case-control Study Pylorus Positivity Enzyme-linked Immunosorbent Assay Stomach Ulcer Received Caga Positivity Publication July Caga Strain Japanese-american Men Hawaiian Island Population Control Confidence Interval Caga Product |
| Content Type | Text |
