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In vitro profiling of the endocrine-disrupting potency of brominated flame retardants (2006).
| Content Provider | CiteSeerX |
|---|---|
| Author | Andersson, Patrik L. Legler, Juliette Brouwer, Abraham |
| Abstract | Over the last few years, increasing evidence has become available that some brominated flame retardants (BFRs) may have endocrine-disrupting (ED) potencies. The goal of the current study was to perform a systematic in vitro screening of the ED potencies of BFRs (1) to elucidate possible modes of action of BFRs in man and wildlife and (2) to classify BFRs with similar profiles of ED potencies. A test set of 27 individual BFRs were selected, consisting of 19 polybrominated diphenyl ether con-geners, tetrabromobisphenol-A, hexabromocyclododecane, 2,4,6-tribromophenol, ortho-hydroxylated brominated diphenyl ether 47, and tetrabromobisphenol-A–bis(2,3)dibromopropyl ether. All BFRs were tested for their potency to interact with the arylhy-drocarbon receptor, androgen receptor (AR), progesterone re-ceptor (PR), and estrogen receptor. In addition, all BFRs were tested for their potency to inhibit estradiol (sulfation by estradiol |
| File Format | |
| Publisher Date | 2006-01-01 |
| Access Restriction | Open |
| Subject Keyword | Endocrine-disrupting Potency Vitro Profiling Brominated Flame Retardant Ed Potency Possible Mode Flame Retardant Estrogen Receptor Last Year Vitro Screening Tetrabromobisphenol-a Bi Androgen Receptor Individual Bfrs Similar Profile Test Set Current Study Dibromopropyl Ether Arylhy-drocarbon Receptor Polybrominated Diphenyl Progesterone Re-ceptor |
| Content Type | Text |
