The expression of p53 tumor suppressor gene in breast cancer cells is down-regulated by cytokine.

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Author	Oncostatin, M. Liu, Jingwen Li, Cong Ahlborn, Thomas E. Spence, Michael J. Meng, Lou Boxer, Linda M.
Abstract	Previously (J. Liu, et al., Cell Growth Differ., 8: 667–676, 1997), we showed that oncostatin M (OM), a cytokine produced by activated T cells and macrophages, inhibited the proliferation of breast cancer cells derived from solid tumors and malignant effusions. OM-treated cells showed reduced growth rates and differentiated phenotypes. Because the p53 tumor suppressor protein plays an important role in cellular proliferation, we examined p53 protein expression in three OM-responsive breast cancer cell lines, MCF-7, MDA-MB231, and H3922. Western blot analysis showed that p53 protein levels in all three of the cell lines were decreased by OM treatment. Reduction of p53 protein was detected after 1 day of OM treatment and reached
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Subject Keyword	Breast Cancer Cell P53 Tumor Suppressor Gene Om Treatment Important Role Activated Cell Cellular Proliferation Cell Line P53 Protein Expression Om-treated Cell P53 Tumor Suppressor Protein P53 Protein Level Reduced Growth Rate Om-responsive Breast Cancer Cell Line P53 Protein Malignant Effusion Cell Growth Differ Differentiated Phenotype Western Blot Analysis Solid Tumor
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