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2xz, united kingdom.wild-type and mutant b-ra c-raf through distinct me involving heterodimerizati.
| Content Provider | CiteSeerX |
|---|---|
| Author | Garnett, Mathew J. Rana, Sareena Paterson, Hugh Barford, David Marais, Richard |
| Abstract | point mutations have been described in B-RAF, the ma-jority clustering to two regions of the kinase domain called the glycine-rich loop and the activation segment appears to mediate the formation of C-RAF:B-RAF het-erodimers (Weber et al., 2001), and, in B-RAF, this con-served site is required to couple signals to MEK (Mac-Nicol et al., 2000). Finally, the binding of 14-3-3 to these conserved sites in the different RAF isoforms appears to be differentially and dynamically regulated (Hekman et al., 2004). |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | United Kingdom Distinct Involving Heterodimerizati Mutant B-ra C-raf Con-served Site B-raf Het-erodimers Activation Segment Kinase Domain Different Raf Isoforms Glycine-rich Loop Point Mutation |
| Content Type | Text |