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Nickel-mediated cross-coupling of benzyl- and 2-methyl-2- phenylpropylmagnesium chloride with aryl bromides (1999).
| Content Provider | CiteSeerX |
|---|---|
| Author | Seo, Yong-Seok Yun, Hee-Sung Park, Kwangyong |
| Abstract | The nickel or palladium catalyzed cross-coupling reac-tions of organic halides or triflates with alkenes (the Heck reaction),1 organoborons (the Suzuki reaction),2 organotins (the Stille reaction)3 and Grignard reagents4,5 are powerful and widely used methods for carbon-carbon bond formation. However, it is generally known that cross-coupling reactions of alkyl organometallic compounds are difficult to conduct in good yields by comparison with aryl or vinyl organome-tallic compounds. A limited number of alkyl Grignard reagents, such as methyl-, several primary alkyl-, cyclopro-pyl-, and allylmagnesium halides, have been reported to react with aryl or vinyl halides to give the corresponding coupling products in moderate yields.5,6 Primary alkyl Grignard reagents, regardless of the presence or the absence of β-hydrogens, were reported to couple with aryl halides |
| File Format | |
| Publisher Date | 1999-01-01 |
| Access Restriction | Open |
| Subject Keyword | 2-methyl-2 Phenylpropylmagnesium Chloride Aryl Bromide Nickel-mediated Cross-coupling Organic Halide Grignard Reagents4 Vinyl Organome-tallic Compound Cross-coupling Reaction Carbon-carbon Bond Formation Allylmagnesium Halide Alkyl Grignard Reagent Vinyl Halide Several Primary Alkyl Cross-coupling Reac-tions Suzuki Reaction Aryl Halide Alkyl Organometallic Compound Grignard Reagent Moderate Yield Stille Reaction Coupling Product Heck Reaction Good Yield Limited Number |
| Content Type | Text |
