NDLI: Relationships between astrogliosis and 1h mr spectroscopic measures of brain choline/creatine and myo-inositol/creatine in a primate model.

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Relationships between astrogliosis and 1h mr spectroscopic measures of brain choline/creatine and myo-inositol/creatine in a primate model.

Content Provider	CiteSeerX
Author	Kim, John P. Lentz, Margaret R. Westmorel, Susan V. Greco, Jane B. Ratai, Eva M. Halpern, Elkan Lackner, Andrew A. Masliah, Eliezer González, R. Gilberto
Abstract	BACKGROUND AND PURPOSE: In vivo 1H MR spectroscopy demonstrates elevated choline (Cho)/creatine (Cr) and myo-inositol (MI)/Cr in many neurologic diseases that has been ascribed to gliosis. We tested the hypotheses that in vivo Cho/Cr and/or MI/Cr levels are correlated with glial fibrillary acidic protein (GFAP) immunostains and that the changes are water-soluble metabolites. METHODS: We performed postmortem 1H MR spectroscopy and GFAP immunohistochem-istry in brains from seven rhesus macaques acutely infected with simian immunodeficiency virus (SIV) and in four controls and compared the findings with previous in vivo MR spectro-scopic results. Changes in neuropathologic and MR spectroscopic markers after infection and relationships among plasma viral load, GFAP immunostaining results, and ex vivo and in vivo MR spectroscopic measures were statistically evaluated. RESULTS: On GFAP immunostaining and in vivoMR spectroscopy, GFAP, Cho/Cr and MI/Cr were highest near the time of peak plasma viral load at 11 days postinfection (dpi). Immunostains returned to baseline by 14 dpi, whereas Cho/Cr and MI/Cr had different time courses, with the former dropping below baseline and the latter remaining elevated. Viral load and immunostains were significantly correlated. No correlation was found between ex vivo Cho/Cr or MI/Cr and viral
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Subject Keyword	Brain Choline Creatine Mr Spectroscopic Measure Mi Cr Cho Cr Myo-inositol Creatine Primate Model Mr Spectroscopy Vivo Cho Cr Water-soluble Metabolite Rhesus Macaque Mr Spectroscopic Marker Mi Cr Level Viral Load Day Postinfection Many Neurologic Disease Glial Fibrillary Acidic Protein Plasma Viral Load Vivomr Spectroscopy Gfap Immunohistochem-istry Vivo Mr Spectroscopic Measure Simian Immunodeficiency Virus Vivo Mr Spectro-scopic Result Peak Plasma Viral Load Gfap Immunostaining Different Time Course Former Dropping
Content Type	Text

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