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Original investigation admixture in mexico city: implications for admixture mapping of type 2 diabetes genetic risk factors.
| Content Provider | CiteSeerX |
|---|---|
| Author | Cruz, Miguel Esteban, Æ Parra, J. |
| Abstract | Abstract Admixture mapping is a recently developed method for identifying genetic risk factors involved in complex traits or diseases showing prevalence differ-ences between major continental groups. Type 2 dia-betes (T2D) is at least twice as prevalent in Native American populations as in populations of European ancestry, so admixture mapping is well suited to study the genetic basis of this complex disease. We have characterized the admixture proportions in a sample of 286 unrelated T2D patients and 275 controls from Mexico City and we discuss the implications of the results for admixture mapping studies. Admixture proportions were estimated using 69 autosomal ancestry-informative markers (AIMs). Maternal and paternal contributions were estimated from geograph-ically informative mtDNA and Y-specific polymor-phisms. The average proportions of Native American, European and, West African admixture were esti-mated as 65, 30, and 5%, respectively. The contribu-tions of Native American ancestors to maternal and paternal lineages were estimated as 90 and 40%, respectively. In a logistic model with higher educa-tional status as dependent variable, the odds ratio for higher educational status associated with an increase from 0 to 1 in European admixture proportions was 9.4 (95%, credible interval 3.8–22.6). This association of socioeconomic status with individual admixture pro-portion shows that genetic stratification in this popu-lation is paralleled, and possibly maintained, by socioeconomic stratification. The effective number of generations back to unadmixed ancestors was 6.7 (95% CI 5.7–8.0), from which we can estimate that genome-wide admixture mapping will require typing about 1,400 evenly distributed AIMs to localize genes underlying disease risk between populations of Euro-pean and Native American ancestry. Sample sizes of about 2,000 cases will be required to detect any locus that contributes an ancestry risk ratio of at least 1.5. |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Genetic Risk Factor Mexico City Admixture Mapping Original Investigation Admixture Admixture Proportion Prevalence Differ-ences Ancestry Risk Ratio Average Proportion Paternal Contribution Educational Status Informative Mtdna Credible Interval Abstract Admixture Mapping Unadmixed Ancestor Native American Effective Number Native American Ancestor West African Admixture Disease Risk Native American Population Paternal Lineage European Ancestry Individual Admixture Pro-portion Show Native American Ancestry Y-specific Polymor-phisms Socioeconomic Status Unrelated T2d Patient Admixture Mapping Study Genetic Stratification Complex Disease Genetic Basis Autosomal Ancestry-informative Marker Complex Trait European Admixture Proportion Odds Ratio Major Continental Group Genome-wide Admixture Mapping Educa-tional Status Logistic Model Dependent Variable Socioeconomic Stratification |
| Content Type | Text |
