NDLI: Ha/tcp compounding of a porous cap biomaterial improves bone formation and scaffold degradation—a long-term (2004).

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Ha/tcp compounding of a porous cap biomaterial improves bone formation and scaffold degradation—a long-term (2004).

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Abstract	Abstract: In the present study, two biphasic calcium phosphate biomaterials (BCP) with HA/TCP ratios of 50/50 and 30/70 were obtained from a pure HA biomaterial. The bioma-terials which showed the same three-dimensional geometry were implanted into corticocan-cellous costal defects of sheep. In the specimens of all three biomaterials, abundant bone formation, mineral dissolution from the biomaterial scaffolds, and active cellular resorption of the scaffolds was present after 6 and 12 months. Backscattered electron microscopy showed bone invasion into the pores of the scaffolds and micromechanical interlocking at the bone/ biomaterial interface without intervening soft tissue. The pattern of bone formation and scaffold resorption was different for cortical and cancellous bone. No time-based effect, however, was observed. Overall, the BCP biomaterials had formed significantly more bone than the HA biomaterial. Also, scaffold resorption, which was followed by a replacement with newly formed bone, was significantly higher in the BCP biomaterials. Although no significant differences were observed between both BCP biomaterials, the present study had confirmed the assumption that HA/TCP compounding was suitable to improve bone formation and scaffold resorption in the investigated biomaterials and at the same time maintain the
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Publisher Date	2004-01-01
Access Restriction	Open
Subject Keyword	Ha Tcp Compounding Scaffold Degradation Scaffold Resorption Bcp Biomaterials Present Study Bone Formation Significant Difference Bone Invasion Biphasic Calcium Phosphate Biomaterials Active Cellular Resorption Backscattered Electron Microscopy Three-dimensional Geometry Corticocan-cellous Costal Defect Mineral Dissolution Micromechanical Interlocking Cancellous Bone Investigated Biomaterials Ha Tcp Ratio Soft Tissue Bone Biomaterial Interface Time-based Effect Biomaterial Scaffold Pure Ha Biomaterial Abundant Bone Formation Ha Biomaterial
Content Type	Text
Resource Type	Article

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