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Immunoglobulin G antibodies against environmental moulds in a Norwegian healthy population shows a bimodal distribution for Aspergillus versicolor
| Content Provider | CiteSeerX |
|---|---|
| Author | Rydjord, B. Hetl, G. Wikerz, H. G. |
| Abstract | Immunoglobulin G (IgG) antibodies against moulds related to indoor dampness problems are used as biomarkers to indicate exposure. In the present study, we evaluated the frequency of mould exposure in an adult healthy population by examining levels of mould-specific IgG antibodies in Norwegian blood donors. Using enzyme-linked immunosorbent assay, 106 blood donor sera were analyzed for IgG antibodies to Aspergillus versicolor, Penicillium chrysogenum, Cladosporium herbarum, Stachybotrys chartarum and Fusarium oxysporum. The levels of specific IgG antibodies to P. chrysogenum, C. herbarum and S. chartarum correlated (r 0.46–0.62). Responses to A. versicolor were considerably stronger than to the other moulds, and another 996 blood donor sera were analyzed for IgG antibodies to this mould. Women had significantly higher levels of specific IgG antibodies to A. versicolor than men. The concentration of A. versicolor-specific IgG antibodies showed a non-Gaussian, bimodal distribution profile, in which 12.5 % were defined as positive to exposure. This suggests that significant mould exposure in a healthy population can be calculated from meanþ 1SD. Western blotting analyses showed that antibody responses to A. versicolor were largely directed against carbohydrate antigens of unknown saccharides. |
| File Format | |
| Journal | Scand J Immunol |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aspergillus Versicolor Bimodal Distribution Immunoglobulin Antibody Environmental Mould Norwegian Healthy Population Specific Igg Antibody Igg Antibody Blood Donor Serum Adult Healthy Population Western Blotting Analysis Unknown Saccharide Healthy Population Carbohydrate Antigen Antibody Response Fusarium Oxysporum Norwegian Blood Donor Penicillium Chrysogenum Present Study Mould Exposure Cladosporium Herbarum Stachybotrys Chartarum Significant Mould Exposure Enzyme-linked Immunosorbent Assay Versicolor-specific Igg Antibody Bimodal Distribution Profile Mould-specific Igg Antibody Dampness Problem |
| Content Type | Text |
| Resource Type | Article |
