NDLI: Dexamethasone alters sleep and fatigue in pediatric patients with acute lymphoblastic leukemia (2007)

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Dexamethasone alters sleep and fatigue in pediatric patients with acute lymphoblastic leukemia (2007)

Content Provider	CiteSeerX
Author	Hinds, Pamela S. Hockenberry, Marilyn J. Gattuso, Jami S. Srivastava, Deo Kumar Tong, Xin Heather Jones, N. West, Nancy Mccarthy, Kathy S. Sadeh, Avi Monica Ash, N. Cheryl Fernandez, N. Md, Ching-Hon Pui
Abstract	BACKGROUND. Dexamethasone improves the cure rate of childhood acute lym-phoblastic leukemia (ALL) but causes physical and behavioral adverse events. The objective of the current study was to determine the effect of dexamethasone exposure on sleep and fatigue in pediatric patients with ALL. METHODS. One hundred pediatric patients with low-risk or standard-risk ALL were enrolled on 1 of 3 protocols (St. Jude Total XV, Children’s Oncology Group [COG] 9904, or COG 9905) at 3 institutions. The mean age of the cohort was 9.24 3.23 years (range, 5.03-18.14 years). The majority of patients were white (79%) males (62%) with standard-risk ALL (63%). The cohort was divided into 4 subgroups: St. Jude low-risk, St. Jude standard-risk, COG low-risk, and COG standard-risk. Patients wore a wrist actigraph to monitor sleep activity during 2 consecutive 5-day periods: During the first period, they did not receive dexa-methasone; and, during the second period, they did. Patients and their parents completed fatigue instruments on Days 2 and 5 of each period, and parents com-pleted sleep diaries.
File Format	PDF
Journal	Cancer
Language	English
Publisher Date	2007-01-01
Access Restriction	Open
Subject Keyword	Pediatric Patient Dexamethasone Alters Acute Lymphoblastic Leukemia Second Period Current Study Cure Rate Consecutive 5-day Period Fatigue Instrument Wrist Actigraph Cog Low-risk First Period Sleep Activity Jude Total Xv Parent Com-pleted Sleep Diary Dexamethasone Exposure Oncology Group Cog Childhood Acute Lym-phoblastic Leukemia Mean Age Behavioral Adverse Event
Content Type	Text
Resource Type	Article

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