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Expressing the modification of diet in renal disease study equation for estimating glomerular filtration rate with standardized serum.
| Content Provider | CiteSeerX |
|---|---|
| Abstract | cation of Diet in Renal Disease (MDRD) Study equation for estimation of glomerular filtration rate (GFR) using serum creatinine (Scr) standardized to reference methods. Methods: Serum specimens included creatinine refer-ence materials prepared by the College of American Pathologists (CAP), traceable to primary reference ma-terial at the NIST, with assigned values traceable to isotope dilution mass spectrometry (IDMS), a calibra-tion panel prepared by the Cleveland Clinic Research Laboratory (CCRL), and frozen samples from the MDRD Study. Split specimens were measured at the CCRL using the Roche enzymatic and Beckman CX3 kinetic alkaline picrate assays. Results: Roche enzymatic assay results on CAP samples were comparable to IDMS-assigned values. Beckman CX3 assay results in 2004–2005 were significantly higher than but highly correlated with simultaneous Roche enzymatic assay results (r2 0.9994 on 40 CCRL sam-ples) and showed minimal but significant upward drift from Beckman CX3 assay results during the MDRD |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Renal Disease Study Equation Standardized Serum Estimating Glomerular Filtration Rate Beckman Cx3 Mdrd Study Frozen Sample Cleveland Clinic Research Laboratory Significant Upward Drift Calibra-tion Panel Simultaneous Roche Enzymatic Assay Result Primary Reference Ma-terial Idms-assigned Value Ccrl Sam-ples American Pathologist Split Specimen Serum Creatinine Roche Enzymatic Assay Result Study Equation Cap Sample Assigned Value Renal Disease Included Creatinine Refer-ence Material Dilution Mass Spectrometry Glomerular Filtration Rate |
| Content Type | Text |
