NDLI: Loss of the nuclear orphan receptor coup-tfii results in the formation of.

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Loss of the nuclear orphan receptor coup-tfii results in the formation of.

Content Provider	CiteSeerX
Author	Malformations, Arteriovenous Lee, Christopher T.
Abstract	The nuclear orphan receptor COUP-TFII is a transcription factor of the steroid/thyroid hormone receptor superfamily. It is primarily expressed in mesenchymal tissues during embryogenesis and is required for normal cardiovascular development. Loss of the COUP-TFII gene in mice results in embryonic lethality due to a variety of cardiovascular abnormalities, including defects in angiogenesis and heart development. To further dene the role of COUP-TFII during cardiovascular development, we have analyzed the cell-specic expression pattern of COUP-TFII within the forming vasculature using gene knock-in, in situ hybridization, and immunohistochemistry techniques. Here we demonstrate in mouse embryos that COUP-TFII is differentially expressed between arteries and veins, suggesting a role for COUP-TFII in arteriovenous differentiation. Furthermore, we show the formation of embryonic arteriovenous malformations in the absence of COUP-TFII, a hallmark of defective arteriovenous differentiation.
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Subject Keyword	Nuclear Orphan Receptor Coup-tfii Result Forming Vasculature Transcription Factor Embryonic Arteriovenous Malformation Gene Knock-in Cell-specic Expression Pattern Cardiovascular Abnormality Cardiovascular Development Embryonic Lethality Coup-tfii Gene Steroid Thyroid Hormone Receptor Immunohistochemistry Technique Nuclear Orphan Receptor Coup-tfii Defective Arteriovenous Differentiation Normal Cardiovascular Development Mouse Embryo Arteriovenous Differentiation Mouse Result Situ Hybridization Heart Development Mesenchymal Tissue
Content Type	Text

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