Fcla chemiluminescence from sonodynamic action in vitro and in vivo.

Content Provider	CiteSeerX
Author	Hea, Yonghong Xinga, Da Yana, Guihong Ken-Ichi 
Abstract	In this work, the chemiluminescence method was engaged for the first time to detect the active oxygen species during sonodynamic action in vitro and in vivo. We used FCLA (3,7-dihydro-6-[4-[2-[N 0-(5-fluoresceinyl)thioureido]-ethoxy]phenyl]-2-methylimidazo[1,2-a]pyrazin-3-one sodium salt), which can selectively react with singlet oxygen (1O2) or superoxide anion (O2 2) to emit photons, to detect in real time oxygen free radical formation in the sonosensitization of hematoporphyrin derivative. The results show that 1O2 is involved in the sonosensitization. In in vivo experiments, a tumor-imaging method by sonodynamic chemiluminescence detection was established. This method could have potential applications in clinics for
File Format	PDF
Access Restriction	Open
Subject Keyword	Sonodynamic Action Fcla Chemiluminescence Vivo Experiment Chemiluminescence Method Sonodynamic Chemiluminescence Detection Active Oxygen Specie Superoxide Anion First Time 2-a Pyrazin-3-one Sodium Salt Singlet Oxygen Phenyl 2-methylimidazo Tumor-imaging Method Potential Application
Content Type	Text