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Reactive trityl derivatives: stabilised carbocation mass-tags for life sciences applications.
| Content Provider | CiteSeerX |
|---|---|
| Author | Ustinov, Alexey V. Shmanai, Vadim V. Patel, Kaajal Stepanova, Irina A. Prokhorenko, Igor A. Astakhova, Irina V. Malakhov, Andrei D. Skorobogatyi, Mikhail V. Bernad, Pablo L. Shahgholi, Mona Southern, Edwin M. Korshun, Vladimir A. Shchepinov, Mikhail S. |
| Abstract | Instrumentation. 500 MHz 1H and 125.7 MHz 13C NMR spectra were recorded on a Bruker DRX-500 spectrometer and referenced to CDCl3 (7.25 ppm) and DMSO-d6 (2.50 ppm). 1H–13C gradient-selected HMQC and HMBC spectra were obtained by using 2048 (t2)×256 (t1) complex point data sets, zero filled to 2048 (F2)×1024 (F1) points. The spectral widths were 13 ppm and 200 ppm for 1H and 13C dimensions, respectively. HMBC spectra were measured with 50 ms delay for evolution of long-range couplings. (MA)LDI-TOF mass spectra were obtained using a Voyager Elite Biospectrometry Research Station (PerSeptive Biosystems, Vestec Mass Spectrometry Products) in a positive ion mode. EI-TOF HRMS and ESI-TOF HRMS spectra in positive ion mode were obtained using Micromass LCT reflection TOF mass spectrometer. Analytical thin-layer chromatography was performed on the Kieselgel 60 F254 precoated aluminium plates (Merck), spots were visualised under UV light (254 nm). Column chromatography was performed on silica gel (Merck Kieselgel 60 0.040–0.063 mm). Reagents and solvents. Reagents obtained from commercial suppliers were used as received. 4-Hydroxy-4′-methoxybenzophenone (3),[1] Pd(PPh3)4,[2] tert-butyl 6-bromohexanoate,[3] were prepared as described. Solvents were mainly HPLC grade and used without further purification |
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| Access Restriction | Open |
| Subject Keyword | Life Science Application Carbocation Mass-tags Reactive Trityl Derivative Hmbc Spectrum Positive Ion Mode 4-hydroxy-4 Methoxybenzophenone Complex Point Data Set Voyager Elite Biospectrometry Research Station Long-range Coupling Esi-tof Hrms Spectrum Gradient-selected Hmqc Nmr Spectrum Column Chromatography Commercial Supplier Ei-tof Hrms Vestec Mass Spectrometry Product Merck Kieselgel Hplc Grade M Delay Aluminium Plate Spectral Width Analytical Thin-layer Chromatography Ldi-tof Mass Spectrum Uv Light Bruker Drx-500 Spectrometer Silica Gel Perseptive Biosystems |
| Content Type | Text |
