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Comparison of physician- and self-collected genital specimens (2005).
| Content Provider | CiteSeerX |
|---|---|
| Author | Wong, X. Zhu W. |
| Abstract | There is currently no consensus regarding the most appropriate methods of sampling for the detection of genital human papillomavirus (HPV) in men. We employed a recently developed collection method involving abrasion and moistened swabbing of the genital skin surface for the detection of HPV in a cohort of 136 university-affiliated males in Hawaii. Genital specimens collected by physicians using this method were compared with self-collected specimens from the same individuals obtained 24 h later. Self-collected specimens yielded a greater proportion of sufficient specimens than physician-collected specimens. HPV detection was comparable in physician- and self-collected specimens; detection was highest in the penile shaft (51.2 % and 51.5%, respectively, P 0.96), followed by the scrotum (41.2 % and 46.2%, P 0.43), the glans/coronal sulcus (31.9 % and 33.1%, P 0.84), and the foreskin (33.3 % and 28.6%, P 0.74). Site-specific agreement in HPV detection between paired physician- and self-collected samples ranged from 67.2 % (kappa 0.34) for the penile shaft to 95.0 % (kappa 0.89) for the foreskin. There was a high degree of concordance in HPV genotypes in HPV-positive pairs. The most common type was HPV type 84, which comprised approximately 15% of the specimens. The emery paper-swab method offers an efficient sampling method for genital HPV DNA detection in men that could be used both within and outside of the clinical setting. Natural-history studies of human papillomavirus (HPV) in- |
| File Format | |
| Publisher Date | 2005-01-01 |
| Access Restriction | Open |
| Subject Keyword | Self-collected Specimen Self-collected Genital Specimen Penile Shaft Hpv Detection Self-collected Sample Emery Paper-swab Method Glans Coronal Sulcus Hpv Type Genital Human Papillomavirus Human Papillomavirus Collection Method High Degree Sufficient Specimen University-affiliated Male Clinical Setting Physician-collected Specimen Natural-history Study Site-specific Agreement Appropriate Method Genital Skin Surface Efficient Sampling Method Hpv Genotype Genital Specimen Genital Hpv Dna Detection Common Type Hpv-positive Pair |
| Content Type | Text |
