Letter 825 aryl, alkyl bis-silyl ethers: rapid access to monoprotected aryl alkyl and biaryl ethers (2003).

Content Provider	CiteSeerX
Author	Access, Rapid Alkyl, Monoprotected Aryl Etherssu, Biaryl Ankala, V. Fenteany, Gabriel
Abstract	Abstract: A simple one-pot procedure has been developed for the selective etherification of aryl silyl ethers in aryl, alkyl bis-silyl ethers to generate alkyl tert-butyldimethylsilyl-protected aryl alkyl ethers and biaryl ethers in good to excellent yields. Key words: protecting groups, phenols, LiOH/DMF, ethers, selec-tive etherification As the complexity of synthetic targets has grown more de-manding, discrimination between similar types of protect-ing groups and direct transformation of one protecting group into another have become essential for increasing the efficiency of natural product synthesis. Among the many protecting groups available for hydroxyl groups, si-lyl and alkyl ethers are the most commonly used due to their stability under various reaction conditions.1 While many procedures are available for the formation of
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Publisher Date	2003-01-01
Access Restriction	Open
Subject Keyword	Alkyl Bis-silyl Ether Biaryl Ether Monoprotected Aryl Alkyl Rapid Access Alkyl Ether Natural Product Synthesis Excellent Yield Protect-ing Group Selec-tive Etherification Key Word Various Reaction Condition Selective Etherification Many Procedure Aryl Silyl Ether Alkyl Tert-butyldimethylsilyl-protected Aryl Alkyl Ether Hydroxyl Group Simple One-pot Procedure Synthetic Target Lioh Dmf Similar Type Direct Transformation
Content Type	Text
Resource Type	Article