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A miniaturized system for spike-triggered intracortical microstimulation in an ambulatory rat (2011).
| Content Provider | CiteSeerX |
|---|---|
| Author | Azin, Meysam Guggenmos, David J. Barbay, Scott Nudo, Olph J. Mohseni, Pedram |
| Abstract | Abstract—This paper reports on a miniaturized system for spike-triggered intracortical microstimulation (ICMS) in an ambulatory rat. The head-mounted microdevice comprises a previously devel-oped application-specific integrated circuit fabricated in 0.35-μm two-poly four-metal complementary metal–oxide–semiconductor technology, which is assembled and packaged on a miniature rigid-flex substrate together with a few external components for programming, supply regulation, and wireless operation. The mi-crodevice operates autonomously from a single 1.55-V battery, measures 3.6 cm × 1.3 cm × 0.6 cm, weighs 1.7 g (including the battery), and is capable of stimulating as well as recording the neu-ral response to ICMS in biological experiments with anesthetized laboratory rats. Moreover, it has been interfaced with silicon mi-croelectrodes chronically implanted in the cerebral cortex of an ambulatory rat and successfully delivers electrical stimuli to the second somatosensory area when triggered by neural activity from the rostral forelimb area with a user-adjustable spike-stimulus time delay. The spike-triggered ICMS is further shown to modulate the neuronal firing rate, indicating that it is physiologically effective. Index Terms—Activity-dependent microstimulation, ambula-tory rat, intracortical microstimulation (ICMS), miniaturized sys- |
| File Format | |
| Publisher Date | 2011-01-01 |
| Access Restriction | Open |
| Subject Keyword | Ambulatory Rat Miniaturized System Spike-triggered Intracortical Microstimulation Neural Activity Intracortical Microstimulation Index Term Activity-dependent Microstimulation Miniature Rigid-flex Substrate Rostral Forelimb Area Supply Regulation External Component Delivers Electrical Stimulus Silicon Mi-croelectrodes Biological Experiment Spike-triggered Icms Cerebral Cortex Anesthetized Laboratory Rat Head-mounted Microdevice Neu-ral Response Two-poly Four-metal Complementary Metal Ambula-tory Rat 55-v Battery User-adjustable Spike-stimulus Time Delay Neuronal Firing Rate Second Somatosensory Area Wireless Operation Semiconductor Technology |
| Content Type | Text |
