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Risk of Colorectal Cancer: A Case-Control Study in
| Content Provider | CiteSeerX |
|---|---|
| Author | Zhou, Bin Li, Yuan Sun, Xiaofeng Zhou, Zongguang Wang, Cun Zhang, Dan Wang, Mojin |
| Abstract | Glucose-regulated protein 78 (GRP78), an endoplasmic reticulum chaperone, up-regulation serves as an efficient mechanism to promote malignant transformation of colorectal cancer (CRC) and protect CRC cells against apoptosis. Recently, the analysis of GRP78 polymorphisms has already determined that GRP78 rs391957 polymorphism could predict clinical outcome in CRC patients. Thus, we tested whether GRP78 polymorphisms are related to the risk of CRC. In this study, we detected two GRP78 polymorphisms (rs391957 (C.T) and rs430397 (G.A)) in 414 CRC cases and 502 hospital-based cancerfree healthy controls in Southwest China using a polymerase chain reaction–restriction fragment length polymorphism technique. Compared with the CC genotype, carriers of CT and TT genotypes of rs391957 polymorphism had higher risks of |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Crc Patient Endoplasmic Reticulum Chaperone Southwest China Protect Crc Cell Colorectal Cancer Clinical Outcome Up-regulation Serf Malignant Transformation Tt Genotype Glucose-regulated Protein Grp78 Polymorphism Case-control Study Efficient Mechanism Cc Genotype Crc Case Rs391957 Polymorphism Hospital-based Cancerfree Healthy Control |
| Content Type | Text |
