NDLI: Short communication lipid peroxidation and antioxidant status in patients with periodontitis (2005).

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Short communication lipid peroxidation and antioxidant status in patients with periodontitis (2005).

Content Provider	CiteSeerX
Author	Panjamurthy, Kuppusamy Manoharan, Shanmugam Ramachandran, Cinnamanoor Rajamani
Abstract	Abstract: Our aim was to assess the degree of oxidative stress in patients with periodontitis by measuring their levels of thiobarbituric acid reactive substances (TBARS), enzymatic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxide (GSHPx)), and non-enzymatic antioxidants (vitamins –E and C, reduced glutathione (GSH)). This study was conducted on 25 adult chronic periodontitis sufferers who were patients in Rajah Muthiah Dental College and Hospital, Annamalai University. The levels of TBARS and non-enzymatic antioxidants, and the activities of enzymatic antioxidants in the patients ' plasma, erythrocytes and gingival tissues were assayed using specific colorimetric methods. The periodontitis sufferers had a significantly higher TBARS level than the healthy subjects. In the plasma, erythrocytes, erythrocyte membranes and gingival tissues of the periodontitis sufferers, enzymatic antioxidant activities were found to be significantly higher, whereas the levels of non-enzymatic antioxidants were significantly lower (except for reduced glutathione in the gingival tissues) relative to the parameters found for healthy subjects. The disturbance in the endogenous antioxidant defense system due to over-production of lipid peroxidation products at inflammatory sites can be related to a higher level of oxidative stress in patients with periodontitis.
File Format	PDF
Publisher Date	2005-01-01
Access Restriction	Open
Subject Keyword	Gingival Tissue Non-enzymatic Antioxidant Oxidative Stress Healthy Subject Enzymatic Antioxidant Periodontitis Sufferer Superoxide Dismutase Erythrocyte Membrane Specific Colorimetric Method Endogenous Antioxidant Defense System Adult Chronic Periodontitis Sufferer Reduced Glutathione Annamalai University Rajah Muthiah Dental College Lipid Peroxidation Product Tbars Level Glutathione Peroxide Inflammatory Site Enzymatic Antioxidant Activity Thiobarbituric Acid Reactive Substance
Content Type	Text
Resource Type	Article

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