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Behavioral/cognitive direct-pathway striatal neurons regulate the retention of decision-making strategies.
| Content Provider | CiteSeerX |
|---|---|
| Author | Ferguson, Susan M. Phillips, Paul E. M. Roth, Bryan L. Wess, Jürgen Neumaier, John F. |
| Abstract | The dorsal striatum has been implicated in reward-based decision making, but the role played by specific striatal circuits in these processes is essentially unknown. Using cell phenotype-specific viral vectors to express engineered G-protein-coupled DREADD (designer receptors exclusively activated by designer drugs) receptors, we enhanced G i/o-orG s-protein-mediated signaling selectively in direct-pathway (striatonigral) neurons of the dorsomedial striatum in Long–Evans rats during discrete periods of training of a high versus low reward-discrimination task. Surprisingly, these perturbations had no impact on reward preference, task performance, or improvement of performance during training. However, we found that transiently increasing G i/o signaling during training significantly impaired the retention of task strategies used to maximize reward obtainment during subsequent preference testing, whereas increasing G s signaling produced the opposite effect and significantly enhanced the encoding of a high-reward preference in this decision-making task. Thus, the fact that the endurance of this improved performance was significantly altered over time—long after these neurons were manipulated—indicates that it is under bidirectional control of canonical G-protein-mediated signaling in striatonigral neurons during training. These data demonstrate that cAMP-dependent signaling in direct-pathway neurons play a well-defined role in reward-related |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Decision-making Strategy Engineered G-protein-coupled Dreadd Well-defined Role Subsequent Preference Testing Reward Preference Dorsomedial Striatum High Versus Low Reward-discrimination Task Reward-based Decision Making High-reward Preference Discrete Period Long Evans Rat Dorsal Striatum Specific Striatal Circuit Task Performance Designer Receptor Designer Drug Task Strategy Reward Obtainment Cell Phenotype-specific Viral Vector Direct-pathway Neuron Decision-making Task Striatonigral Neuron Opposite Effect Bidirectional Control Improved Performance Canonical G-protein-mediated Signaling |
| Content Type | Text |
