DOI 10.1007/s11682-007-9003-2 Glucocorticoids Decrease Hippocampal and Prefrontal Activation during Declarative Memory Retrieval in Young Men (2007)

Content Provider	CiteSeerX
Author	Damoiseaux, Jessica S. Elzinga, Bernet M. Oei, Nicole Y. L. Ruiter, Michiel B. De Wolf, O. T. Kuijer, Joost P. A. Rombouts, Serge A. R. B. Ruiter, M. B. De Wolf, Oliver T. Veltman, Dick J. Scheltens, Philip
Abstract	Abstract Glucocorticoids (GCs, cortisol in human) are associated with impairments in declarative memory retrieval. Brain regions hypothesized to mediate these effects are the hippocampus and prefrontal cortex (PFC). Our aim was to use fMRI in localizing the effects of GCs during declarative memory retrieval. Therefore, we tested memory retrieval in 21 young healthy males in a randomized placebo-controlled crossover design. Participants encoded word lists containing neutral and emotional words 1 h prior to ingestion of 20 mg hydrocortisone. Memory retrieval was tested using an old/new recognition paradigm in a rapid event-related design. It was found that hydrocortisone decreased brain activity in both the hippocampus and PFC during successful retrieval of neutral words. These observations are consistent with previous animal and
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Publisher Date	2007-01-01
Access Restriction	Open
Subject Keyword	Rapid Event-related Design Brain Region Word List Mg Hydrocortisone Neutral Word Declarative Memory Retrieval Previous Animal Prefrontal Activation Prefrontal Cortex Randomized Placebo-controlled Crossover Design Memory Retrieval Young Men Abstract Glucocorticoid Successful Retrieval Young Healthy Male Old New Recognition Paradigm S11682-007-9003-2 Glucocorticoid Decrease Hippocampal Emotional Word Brain Activity
Content Type	Text