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Gelsolin-independent podosome formation in dendritic (2011).
| Content Provider | CiteSeerX |
|---|---|
| Author | Hammarfjord, Oscar Falet, Hervé Gurniak, Christine Hartwig, John H. Wallin, Robert P. A. |
| Abstract | Podosomes, important structures for adhesion and extracellular matrix degradation, are claimed to be involved in cell migration. In addition, podosomes are also reported to be of importance in tissue remodelling, e.g., in osteoclast-mediated bone resorption. Podosomes are highly dynamic actin-filament scaffolds onto which proteins important for their function, such as matrix metallo-proteases and integrins, attach. The dynamics of the podosomes require the action of many proteins regulating actin assembly and disassembly. One such protein, gelsolin, which associates to podosomes, has been reported to be important for podosome formation and function in osteoclasts. However, podosome-like structures have been reported in gelsolin-deficient dendritic cells, but the identity of these structures was not confirmed, and their dynamics and function was not investigated. Like many other cells, dendritic cells of the immune system also form matrix degrading podosomes. In the present study, we show that dendritic cells form podosomes independently of gelsolin, that there are no major alterations in their dynamics of formation and disassembly, and that they exhibit matrix-degrading function. Furthermore, we found that gelsolin is not required for TLR4-induced podosome disassembly. Thus, the actin cytoskeleton of podosomes involved in dendritic cell extracellular matrix degradation appears to be regulated differently than the |
| File Format | |
| Publisher Date | 2011-01-01 |
| Access Restriction | Open |
| Subject Keyword | Gelsolin-independent Podosome Formation Dendritic Cell Matrix Metallo-proteases Immune System Dynamic Actin-filament Scaffold Dendritic Cell Extracellular Matrix Degradation Cell Migration Many Protein Tissue Remodelling Tlr4-induced Podosome Podosome Formation Matrix-degrading Function Gelsolin-deficient Dendritic Cell Podosome-like Structure Major Alteration Extracellular Matrix Degradation Present Study Actin Assembly Dendritic Cell Form Podosomes Many Cell Important Structure Osteoclast-mediated Bone Resorption |
| Content Type | Text |
