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Clusterin expression in colorectal tissue.
| Content Provider | CiteSeerX |
|---|---|
| Abstract | publicly available data indicating the existence of multiple novel CLU transcripts, the task of evaluating the evidence for these transcripts and to validate their possible expression has not yet been addressed. Knowledge of all potential CLU transcripts is of utmost importance when designing oligos for silencing CLU translation using the novel antisense therapeutic strategy mentioned above. Silencing CLU translation is of interest for the treatment of all cancers that overexpress CLU, including bladder, breast, lung, and potentially also colorectal cancer (CRC) (1). However, previous studies on CLU expression in CRC have disagreed on whether CLU is up-regulated (7, 15) or downregulated by the cancer cells (16). There are many possible explanations for the inconsistent observations, e.g. analysis of different CLU variants caused by the use of different antibodies |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Colorectal Tissue Clusterin Expression Clu Translation Clu Expression Possible Expression Inconsistent Observation Colorectal Cancer Previous Study Different Antibody Multiple Novel Clu Transcript Many Possible Explanation Potential Clu Transcript Available Data Novel Antisense Therapeutic Strategy Utmost Importance Different Clu Variant Cancer Cell |
| Content Type | Text |
