Loading...
Please wait, while we are loading the content...
Similar Documents
Vanadium induced b-dependent transcription depends upon peroxide-induced activation of the p38 mitogen-activated protein kinase (2000).
| Content Provider | CiteSeerX |
|---|---|
| Author | Jaspers, Ilona Samet, James M. Erzurum, Serpil Reed, William |
| Abstract | Activation of nuclear factor (NF)-�B and subsequent proinflammatory gene expression in human airway epithelial cells can be evoked by oxidative stress. In this study we examined signal transduction pathways activated by vanadyl sulfate (V IV)–induced oxidative stress in normal human bronchial epithelial cells. Both nuclear translocation of NF-�B and enhanced �B-dependent transcription induced by V IV were inhibited by overexpression of catalase, but not Cu,Zn superoxide dismutase (Cu,Zn-SOD), indicating that peroxides rather than superoxides initiated signaling. Catalase selectively blocked the response to V IV because it inhibited neither NF-�B translocation nor �B-dependent transcription evoked by the proinflammatory cytokine tumor necrosis factor (TNF)-�. The V IV-induced �B-dependent transcription was dependent upon activation of the p38 mitogen-activated protein kinase because |
| File Format | |
| Publisher Date | 2000-01-01 |
| Access Restriction | Open |
| Subject Keyword | B-dependent Transcription P38 Mitogen-activated Protein Kinase Peroxide-induced Activation Zn Superoxide Dismutase Human Airway Epithelial Cell Normal Human Bronchial Epithelial Cell Proinflammatory Cytokine Tumor Necrosis Factor Nuclear Factor Iv-induced B-dependent Transcription Nf Translocation Nuclear Translocation Subsequent Proinflammatory Gene Expression Signal Transduction Pathway Vanadyl Sulfate |
| Content Type | Text |