Loading...
Please wait, while we are loading the content...
Similar Documents
Ionic currents and spontaneous firing in neurons isolated from the cerebellar nuclei.
| Content Provider | CiteSeerX |
|---|---|
| Author | Raman, Indira M. Gustafson, Amy E. Padgett, Daniel |
| Abstract | Neurons of the cerebellar nuclei fire spontaneous action potentials both in vitro, with synaptic transmission blocked, and in vivo, in resting animals, despite ongoing inhibition from spontaneously active Purkinje neurons. We have studied the intrinsic currents of cerebellar nuclear neurons isolated from the mouse, with an interest in understanding how these currents generate spontaneous activity in the absence of synaptic input as well as how they allow firing to continue during basal levels of inhibition. Current-clamped isolated neurons fired regularly (�20 Hz), with shallow interspike hyperpolarizations (approximately �60 mV), much like neurons in more intact preparations. The spontaneous firing frequency lay in the middle of the dynamic range of the neurons and could be modulated up or down with small current injections. During step or action potential waveform voltage-clamp commands, |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Ionic Current Spontaneous Firing Cerebellar Nucleus Neuron Isolated Small Current Injection Synaptic Transmission Dynamic Range Intrinsic Current Cerebellar Nuclear Neuron Active Purkinje Neuron Basal Level Spontaneous Activity Synaptic Input Current-clamped Isolated Neuron Shallow Interspike Hyperpolarizations Action Potential Waveform Voltage-clamp Command Spontaneous Firing Frequency Intact Preparation |
| Content Type | Text |
