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Noxious thermal and chemical stimulation induce increases in 3h-phorbol 12,13=dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase c.
| Content Provider | CiteSeerX |
|---|---|
| Author | Yashpal, Kiran Pitcher, Graham M. Parent, Angele Quirion, Rbmi Coderre, Terence J. |
| Abstract | We have previously suggested that protein kinase C (PKC) contributes to persistent pain in the formalin test. This study compared the effects of pharmacological inhibition of PKC with either GF 109203X or chelerythrine on persistent pain following noxious chemical stimulation with its effects on mechanical hyperalgesia, which develops in the hindpaw contralateral to an injury produced by noxious thermal stimulation. Furthermore, we have assessed changes in membrane-associated PKC in spinal cord in response to both noxious chemical and thermal stimulation. Nociceptive responses, to a hindpaw injection of 50 PI of 2.5 % formalin, and flexion reflex thresholds, to mechanical stimulation (Randall-Selitto test) in the hindpaw contralateral to a thermal injury (15 set immersion in water at 55”(Z), were assessed following intrathecal injection of PKC inhibitors |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Persistent Pain Protein Kinase Chemical Stimulation Induce Spinal Cord Dorsal Horn Dibutyrate Binding Noxious Thermal Hindpaw Contralateral Noxious Chemical Stimulation Thermal Injury Randall-selitto Test Noxious Chemical Pkc Inhibitor Nociceptive Response Hindpaw Injection Spinal Cord Mechanical Hyperalgesia Pharmacological Inhibition Mechanical Stimulation Thermal Stimulation Noxious Thermal Stimulation Membrane-associated Pkc Intrathecal Injection Flexion Reflex Threshold Formalin Test |
| Content Type | Text |
