Isoflurane reduces glutamatergic transmission in neurons in the spinal cord superficial dorsal horn: evidence for a presynaptic site of an analgesic action.

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Abstract	The minimum alveolar concentration (MAC) of a volatile anesthetic defines anesthetic potency in terms of a suppressed motor response to a noxious stimulus. Therefore, the MAC of an anesthetic might in part reflect depression of motor neuron excitability. In the present study we evaluated the effect of isoflurane (ISO) on neurons in the substantia gelatinosa driven synaptically by putative nociceptive inputs in an in vitro spinal cord preparation of the rat. Whole-cell patchclamp recordings were performed in neurons with their soma in the substantia gelatinosa of transverse rat spinal cord slices. We investigated the effect of ISO on excitatory postsynaptic currents (EPSC) evoked by dorsal root stimulation (eEPSC), spontaneous (sEPSC), and miniature (mEPSC) EPSC. ISO reversibly reduced the
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Subject Keyword	Spinal Cord Superficial Dorsal Horn Isoflurane Reduces Glutamatergic Transmission Presynaptic Site Analgesic Action Substantia Gelatinosa Noxious Stimulus Present Study Vitro Spinal Cord Preparation Motor Neuron Excitability Minimum Alveolar Concentration Suppressed Motor Response Dorsal Root Stimulation Putative Nociceptive Input Transverse Rat Spinal Cord Slice Excitatory Postsynaptic Current Volatile Anesthetic Defines Anesthetic Potency Whole-cell Patchclamp Recording
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