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The Agrin/MuSK signaling pathway is spatially segregated from the neuregulin/ErbB receptor signaling pathway at the neuromuscular junction (2000)
| Content Provider | CiteSeerX |
|---|---|
| Author | Trinidad, Jonathan C. Fischbach, Gerald D. Cohen, Jonathan B. |
| Abstract | The neuregulin/erbB receptor and agrin/MuSK pathways are critical for communication between the nerve, muscle, and Schwann cell that establishes the precise topological arrangement at the vertebrate neuromuscular junction (NMJ). ErbB2, erbB3, and erbB4 as well as neuregulin, agrin, and MuSK are known to be concentrated at the NMJ. Here we have examined NMJs from gastrocnemius muscle of adult rat using immunofluorescence confocal microscopy to characterize in detail the distribution of these proteins relative to the distribution of acetylcholine receptors (AChRs). We have determined that erbB2 and erbB4 are enriched in the depths of the secondary junctional folds on the postsynaptic muscle membrane. In contrast, erbB3 at the NMJ was concentrated at presynaptic terminal Schwann cells. This distribution strongly argues that erbB2/erbB4 heterodimers are the functional postsynaptic neuregulin receptors of |
| File Format | |
| Journal | J Neurosci |
| Language | English |
| Publisher Date | 2000-01-01 |
| Access Restriction | Open |
| Subject Keyword | Neuregulin Erbb Receptor Neuromuscular Junction Agrin Musk Precise Topological Arrangement Secondary Junctional Fold Immunofluorescence Confocal Microscopy Adult Rat Erbb2 Erbb4 Heterodimers Gastrocnemius Muscle Presynaptic Terminal Schwann Cell Vertebrate Neuromuscular Junction Functional Postsynaptic Neuregulin Receptor Agrin Musk Pathway Acetylcholine Receptor Postsynaptic Muscle Membrane |
| Content Type | Text |
| Resource Type | Article |
