Lack of neurotrophin-4 causes selective structural and chemical deficits in sympathetic ganglia and their preganglionic innervation.

Content Provider	CiteSeerX
Author	Roosen, Er Schober, Andreas Strelau, Jens Böttner, Martina Faulhaber, Jörg Bendner, Gerald Mcilwrath, Sabrina L. Seller, Horst Ehmke, Heimo Lewin, Gary R. Unsicker, Klaus
Abstract	Neurotrophin-4 (NT-4) is perhaps the still most enigmatic member of the neurotrophin family. We show here that NT-4 is expressed in neurons of paravertebral and prevertebral sympathetic ganglia, i.e., the superior cervical (SCG), stellate (SG), and celiac (CG) ganglion. Mice deficient for NT-4 showed a significant reduction (20–30%) of preganglionic sympathetic neurons in the intermediolateral column (IML) of the thoracic spinal cord. In contrast, neuron numbers in the SCG, SG, and CG were unchanged. Numbers of axons in the thoracic sympathetic trunk (TST) connecting the SG with lower paravertebral ganglia were also reduced, whereas axon numbers in the cervical sympathetic trunk (CST) were unaltered. Axon losses in the TST were paralleled by losses of synaptic terminals on SG neurons visualized by electron microscopy. Furthermore, immunoreactivity for the synaptic vesicle antigen SV2 was clearly
File Format	PDF
Access Restriction	Open
Subject Keyword	Preganglionic Innervation Chemical Deficit Sympathetic Ganglion Neurotrophin-4 Cause Selective Structural Preganglionic Sympathetic Neuron Neurotrophin Family Axon Number Sg Neuron Thoracic Spinal Cord Electron Microscopy Intermediolateral Column Cervical Sympathetic Trunk Thoracic Sympathetic Trunk Significant Reduction Mouse Deficient Axon Loss Neuron Number Prevertebral Sympathetic Ganglion Synaptic Terminal Synaptic Vesicle Antigen Sv2 Enigmatic Member Paravertebral Ganglion
Content Type	Text