N-cadherin redistribution during synaptogenesis in hippocampal neurons (1998)

Content Provider	CiteSeerX
Author	Benson, Deanna L. Tanaka, Hidekazu
Abstract	Cadherins are homophilic adhesion molecules that, together with their intracellular binding partners the catenins, mediate adhesion and signaling at a variety of intercellular junctions. This study shows that neural (N)-cadherin and �-catenin, an intracellular binding partner for the classic cadherins, are present in axons and dendrites before synapse formation and then cluster at developing synapses between hippocampal neurons. N-cadherin is expressed initially at all synaptic sites but rapidly becomes restricted to a subpopulation of excitatory synaptic sites. Sites of GABAergic, inhibitory synapses in mature cultures therefore lack N-cadherin but are associated with clusters of �-catenin, implying that they contain a different classic cadherin. These findings indicate that N-cadherin adhesion may stabilize early synapses that can then be remodeled to express a different cadherin and that cadherins systematically
File Format	PDF
Journal	J Neurosci
Language	English
Publisher Date	1998-01-01
Access Restriction	Open
Subject Keyword	Hippocampal Neuron N-cadherin Redistribution Intracellular Binding Partner Synaptic Site Intercellular Junction Different Classic Cadherin Mature Culture Early Synapsis Excitatory Synaptic Site Mediate Adhesion Homophilic Adhesion Molecule Classic Cadherins Different Cadherin Inhibitory Synapsis Synapse Formation N-cadherin Adhesion
Content Type	Text
Resource Type	Article