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Gdnf protection against 6-ohda: time dependence and requirement for protein synthesis.
| Content Provider | CiteSeerX |
|---|---|
| Author | Kearns, Cecilia M. Cass, Wayne A. Smoot, Kyle Kryscio, Richard Gash, Don M. |
| Abstract | Glial cell line-derived neurotrophic factor (GDNF) injected intranigrally protects midbrain dopamine neurons against 6-hydroxydopamine (6-OHDA) toxicity. The timing between GDNF administration and exposure to 6-OHDA is critical in achieving optimal protection. When injected 6 hr before an intranigral injection of 6-OHDA, GDNF provides complete protection as measured by the number of surviving neurons in the substantia nigra of adult rats. The surviving neuronal population decreases by �50 % with 12 and 24 hr separating GDNF and 6-OHDA administrations. In controls with 6-OHDA lesions, there is �10 % survival of nigral dopamine neurons. No significant increase in survival is seen with either concurrent injections of GDNF and 6-OHDA or 1 hr GDNF pretreatment. Based on HPLC measurements, striatal and midbrain dopamine levels are at least twofold higher on the lesioned side in animals |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Time Dependence Gdnf Protection Protein Synthesis Midbrain Dopamine Level Hplc Measurement Significant Increase 6-ohda Lesion Adult Rat Gdnf Administration Optimal Protection Hr Gdnf Pretreatment Nigral Dopamine Neuron Neuronal Population Decrease Intranigral Injection Midbrain Dopamine Neuron 6-ohda Administration Lesioned Side Glial Cell Line-derived Neurotrophic Factor Concurrent Injection Complete Protection |
| Content Type | Text |
