The Acute Toxicity and Hematological Characterization of the Effects of Tentacle-Only Extract from the Jellyfish (2011)

Content Provider	CiteSeerX
Author	Xiao, Liang Wang, Qianqian Liu, Guoyan Zhang, Liming Nie, Fei Capillata, Cyanea Liu, Sihua Zhao, Jie He, Qian Ye, Xuting
Abstract	Abstract: To investigate the hematologic changes and the activities of jellyfish venoms other than hemolytic and cardiovascular toxicities, the acute toxicity of tentacle-only extract (TOE) from the jellyfish Cyanea capillata was observed in mice, and hematological indexes were examined in rats. The median lethal dose (LD50) of TOE was 4.25 mg/kg, and the acute toxicity involved both heart- and nervous system-related symptoms. Arterial blood gas indexes, including pH, PCO2, HCO3 − , HCO3std, TCO2, BEecf and BE (B), decreased significantly. PO2 showed a slight increase, while SO2c (%) had no change at any time. Na + and Ca 2+ decreased, but K + increased. Biochemical indexes, including LDH, CK, CK-MB, ALT, AST and sCr, significantly increased. Other biochemical indexes, including BUN and hemodiastase, remained normal. Lactic acid significantly increased, while glucose, Hct % and THbc showed slight temporary increases and then returned to normal. These results on the acute toxicity and hematological changes should improve our understanding of the in vivo pathophysiological effects of TOE from C. capillata and indicate that it may alsoMar. Drugs 2011, 9 527
File Format	PDF
Publisher Date	2011-01-01
Access Restriction	Open
Content Type	Text
Resource Type	Article