NDLI: Protein family review the adf/cofilin family: actin-remodeling proteins (2002).

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Protein family review the adf/cofilin family: actin-remodeling proteins (2002).

Content Provider	CiteSeerX
Author	Maciver, K. Hussey, Patrick J.
Abstract	Summary The ADF/cofilins are a family of actin-binding proteins expressed in all eukaryotic cells so far examined. Members of this family remodel the actin cytoskeleton, for example during cytokinesis, when the actin-rich contractile ring shrinks as it contracts through the interaction of ADF/cofilins with both monomeric and filamentous actin. The depolymerizing activity is twofold: ADF/cofilins sever actin filaments and also increase the rate at which monomers leave the filament’s pointed end. The threedimensional structure of ADF/cofilins is similar to a fold in members of the gelsolin family of actinbinding proteins in which this fold is typically repeated three or six times; although both families bind polyphosphoinositide lipids and actin in a pH-dependent manner, they share no obvious sequence similarity. Plants and animals have multiple ADF/cofilin genes, belonging in vertebrates to two types, ADF and cofilins. Other eukaryotes (such as yeast, Acanthamoeba and slime moulds) have a single ADF/cofilin gene. Phylogenetic analysis of the ADF/cofilins reveals that, with few exceptions, their relationships reflect conventional views of the relationships between the major groups of organisms. Actin-binding proteins modulate the actin-based cytoskeleton; together, they form, destroy and reform the vast array of
File Format	PDF
Publisher Date	2002-01-01
Access Restriction	Open
Subject Keyword	Adf Cofilins Actin-remodeling Protein Protein Family Actin-binding Protein Conventional View Slime Mould Single Adf Cofilin Gene Ph-dependent Manner Multiple Adf Cofilin Gene Filamentous Actin Actin Filament Actin-based Cytoskeleton Vast Array Obvious Sequence Similarity Gelsolin Family Phylogenetic Analysis Threedimensional Structure Eukaryotic Cell Depolymerizing Activity Polyphosphoinositide Lipid Major Group Actin-rich Contractile
Content Type	Text

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