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Bluckage of cell-to-cell communication within pancreatic acini is associated with increased basal release of amylase (1986)
| Content Provider | CiteSeerX |
|---|---|
| Author | Meda, Paolo Bruzzone, Roberto Knodel, Ra Orci, Lelio |
| Abstract | Abstract. To assess whether junctional coupling is involved in the secretory activity of pancreatic acinar cells, dispersed rat acini were incubated for 30 min in the presence of either heptanol (3.5 mM) or octanol (1.0 mM). Exposure to either alkanol caused a marked uncoupling of the acinar cells which, in control acini, were extensively coupled. Uncoupling was associated with an increased basal release of amylase that was at least twice that of controls. By contrast, carbamylcholine (10-5 M)-induced maximal amylase secretion, cytosolic pH, and free Ca 2รท, as well as the structure of gap junctions joining the acinar cells, were unaffected. Both uncoupling and the alteration of basal secretion were already observed after only 5 rain of exposure to heptanol, they both persisted throughout the 30-rain |
| File Format | |
| Journal | J. Cell |
| Language | English |
| Publisher Date | 1986-01-01 |
| Access Restriction | Open |
| Subject Keyword | Basal Release Pancreatic Acinus Cell-to-cell Communication Acinar Cell Cytosolic Ph Pancreatic Acinar Cell Gap Junction Secretory Activity Basal Secretion Marked Uncoupling Maximal Amylase Secretion Free Ca Control Acinus Junctional Coupling Rat Acinus |
| Content Type | Text |
| Resource Type | Article |
