The Novel Carbohydrate Epitope L3 Is Shared by Some Neural Cell Adhesion Molecules

Content Provider	CiteSeerX
Author	Schachner, Melitta Faissner, Andreas Kiicherer, Andrea
Abstract	Abstract. The monoclonal L3 antibody reacts with an N-glycosidically linked carbohydrate structure on at least nine glycoproteins of adult mouse brain. Three out of the L3 epitope-carrying glycoproteins could be identified as the neural cell adhesion molecules L1 and myelin-associated glycoprotein, and the novel adhesion molecule on glia. Expression of the L3 carbohydrate epitope is regulated independently of the protein backbone of these three glycoproteins. Based on the obser-vation that out of three functionally characterized L3 epitope-carrying glycoproteins three fulfill the operational definition of an adhesion molecule, we would like to suggest that they form a new family of adhesion molecules that is distinct from the L2/HNK-1 carbohydrate epitope family of neural cell adhesion molecules.
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Subject Keyword	L3 Epitope-carrying Glycoprotein Adhesion Molecule Neural Cell Adhesion Molecule L1 Neural Cell Adhesion Molecule Adult Mouse Brain Novel Adhesion Molecule Carbohydrate Structure Operational Definition L2 Hnk-1 Carbohydrate Epitope Family Protein Backbone Myelin-associated Glycoprotein Novel Carbohydrate Epitope L3 L3 Carbohydrate Epitope Monoclonal L3 Antibody
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Resource Type	Article