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Compartmentalization of integrin 64 signaling in lipid rafts (2003)
| Content Provider | CiteSeerX |
|---|---|
| Author | Gagnoux-Palacios, Laurent Dans, Michael Hof, Wouter Van’t. Mariotti, Agnese Pepe, Angela Meneguzzi, Guerrino Resh, Marilyn D. |
| Abstract | Integrin �6�4 signaling proceeds through Src family kinase (SFK)–mediated phosphorylation of the cytoplasmic tail of �4, recruitment of Shc, and activation of Ras and phosphoinositide-3 kinase. Upon cessation of signaling, �6�4 mediates assembly of hemidesmosomes. Here, we report that part of �6�4 is incorporated in lipid rafts. Metabolic labeling in combination with mutagenesis indicates that one or more cysteine in the membrane-proximal segment of �4 tail is palmitoylated. Mutation of these cysteines suppresses incorporation of �6�4 in lipid rafts, but does |
| File Format | |
| Journal | J. Cell |
| Language | English |
| Publisher Date | 2003-01-01 |
| Access Restriction | Open |
| Subject Keyword | Lipid Raft Phosphoinositide-3 Kinase Membrane-proximal Segment Cysteine Suppresses Incorporation Src Family Kinase Cytoplasmic Tail Signaling Proceeds |
| Content Type | Text |
| Resource Type | Article |
