Prediction of Biological Functions on Glycosylation Site Migrations in Human Influenza H1N1 Viruses (2011)

Content Provider	CiteSeerX
Author	Zhao, Fei Li, Zheng Chen, Wentian Wang, Qinzhe Sun, Shisheng
Abstract	Protein glycosylation alteration is typically employed by various viruses for escaping immune pressures from their hosts. Our previous work had shown that not only the increase of glycosylation sites (glycosites) numbers, but also glycosite migration might be involved in the evolution of human seasonal influenza H1N1 viruses. More importantly, glycosite migration was likely a more effectively alteration way for the host adaption of human influenza H1N1 viruses. In this study, we provided more bioinformatics and statistic evidences for further predicting the significant biological functions of glycosite migration in the host adaptation of human influenza H1N1 viruses, by employing homology modeling and in silico protein glycosylation of representative HA and NA proteins as well as amino acid variability analysis at antigenic sites of HA and NA. The results showed that glycosite migrations in human influenza viruses have at least five possible functions: to more effectively mask the antigenic sites, to more effectively protect the enzymatic cleavage sites of neuraminidase (NA), to stabilize the polymeric structures, to regulate the receptor binding and catalytic activities and to balance the binding activity of hemagglutinin (HA) with the release activity of NA. The information here can provide some constructive suggestions for the function research related to protein glycosylation of influenza viruses, although these predictions still
File Format	PDF
Publisher Date	2011-01-01
Access Restriction	Open
Subject Keyword	Human Influenza Virus Glycosite Migration Biological Function Immune Pressure Release Activity Glycosylation Site Migration Catalytic Activity Possible Function Polymeric Structure Enzymatic Cleavage Site Representative Ha Various Virus Alteration Way Statistic Evidence Antigenic Site Constructive Suggestion Significant Biological Function Human Seasonal Influenza H1n1 Variability Analysis Host Adaption Glycosylation Site Protein Glycosylation Alteration Host Adaptation Receptor Binding Function Research Binding Activity Homology Modeling Silico Protein Glycosylation Human Influenza H1n1 Virus
Content Type	Text